Statins: Benefits for High Risk Patients and Side Effects

Lipitor, Crestor, Zocor.  Names that have become very familiar in most American homes.  Statins are among the most commonly prescribed medications for lowering cholesterol and may be responsible for saving thousands of people plagued by heart disease.

But are statins really the miracle drugs many doctors claim for them to be? There are some serious side-effects associated with statins, often overlooked.  So before resorting to a long-term commitment with a pill, ask yourself, “Are the side-effects worth the potential benefit?”

Statins work by blocking a substance your liver needs to make cholesterol, the waxy substance that’s found in fat in your blood. This causes your liver to remove cholesterol from your blood. While your body needs cholesterol to build healthy cells, having high cholesterol can increase your risk of heart disease.  When you have high cholesterol, you are at risk of developing deposits of fat in your blood vessels. Eventually, these deposits impede the flow of blood through your arteries. If your heart does not get as much oxygen-rich blood as it needs, your risk of heart attack is greatly increased.   Similarly, decreased blood flow to your brain, due to clogged arteries, can cause a stroke.  Because of the serious risks that accompany high cholesterol, statins have been a choice favorite among doctors to avoid atherosclerosis, coronary artery disease, heart attack and stroke.  What is discussed less often, are the risks and side effects of this group of drugs.  If you, or a loved one is taking a statin, or is considering taking one to lower cholesterol familiarize yourself with the following potential side effects.

  • Muscle pain and damage: The most common side effect of statins is muscle pain, characterized by a soreness, tiredness or weakness in your muscles. Pain varies among people who take statins from mild discomfort to severe pain which impedes daily activity. Things as simple as climbing stairs, or taking a stroll can become uncomfortable or even unbearable. A common test used by physicians to ascertain whether there is muscle injury or muscle stress, is a CPK isoenzymes test.  This simple blood test measures CPK (creatinine phosphokinase), an enzyme found mainly in heart, brain, and skeletal muscle.  If elevated, it could mean muscle injury.
  • Liver damage: Statin use can occasionally cause your liver damage or stress.   Signs of possible liver damage could be unusual fatigue or weakness, loss of appetite, pain in your upper abdomen, dark-colored urine, or yellowing of your skin or eyes. Because an excess of liver enzymes in the blood is usually a good indicator of compromised liver function, your doctor will most likely order a liver enzyme test either after you begin taking a statin or if you are experiencing any severe symptoms.  In cases where liver enzymes are severely elevated, your doctor may advise you stop taking the drug all together.
  • Neurological side effects: The FDA (Food and Drug Administration) warns of memory loss and confusion as a side effect of statin use. These side effects are said to last only as long as you are taking the medication.  The neurological side-effects have not been well studied, however if you experience either of the above symptoms consult your physician.
  • Increased blood sugar or type 2 diabetes: Another FDA issued warning regarding statins that deserves attention is the increased risk of elevated blood sugar levels, which can lead to type 2 diabetes.  Risk is said to be small, however it is still important to take note of.
  • Other side-effects: Some other side-effects which have been reported to accompany statin use are digestive problems – such as nausea, constipation, or diarrhea –  rash, or skin flushing

High cholesterol (hypercholesterolemia) can be inherited, but it is often the result of unhealthy lifestyle choices, and thus preventable and treatable.

You are more likely to have high cholesterol if one, or more, of the following applies to you:

      • Smoking
      • Obesity
      • Poor diet
      • Lack of exercise
      • High blood pressure
      • Diabetes
      • Family history of heart disease

A healthy diet – low-fat, low-salt diet that includes many fruits, vegetables and whole grains – regular exercise, and an overall healthy lifestyle can help you keep your cholesterol in check.  There are also a number of natural alternatives to taking statins, including garlic, blond psyllium (found in Metamucil), artichoke, and barley and oat bran.  A healthy lifestyle and natural alternatives should be your first line of defense against high cholesterol.  However, as mentioned, there are also genetic factors associated with hypercholesterolemia.  We urge you to discuss the risks and benefits of statins with your physician to decide whether they are right for you.  If you must take statins to maintain heart health, then be aware of the side effects and contact your doctor if you experience any of the side effects discussed.

David Samadi, MD - Medical Contributor

View posts by David Samadi, MD - Medical Contributor
Dr. Samadi is a board-certified urologic oncologist trained in open and traditional and laparoscopic surgery and is an expert in robotic prostate surgery. He is chairman of urology, chief of robotic surgery at Lenox Hill Hospital and professor of urology at Hofstra North Shore-LIJ School of Medicine. He is a medical correspondent for the Fox News Channel's Medical A-Team. Learn more at Visit Dr. Samadi's blog at Follow Dr. Samadi on Twitter, Instagram, Pinterest, and Facebook.
Scroll to top