Could Researchers Have Discovered a Cure for Baldness?

One of the harder moments in adulthood comes at the realization that you’re getting older.  It doesn’t fully sink in, however, until that exact moment when you look in the bathroom mirror and start to see your hair thinning.  You are losing a little bit of yourself with every strand. Every memory of combing your hair before picture day in school, shaving your head for summer swim meets, growing it long in winter to keep your head warm, are all fading.  One truth is all that matters now, and that is that you will never have what you once did.  You will forever be looking in the mirror to see how much is gone.Balding Man

In the US alone, about 35 million men are currently experiencing hair loss.  Additionally, 21 million women in the US suffer from hair loss.  Mistakenly thought to be a strictly male disease, women actually make up forty percent of American hair loss sufferers.

Could a new study just released by Columbia University Medical Center in New York City and the University of Durham in England hold the key to curing baldness? Not quite yet, but researchers claim this discovery could “revolutionize” the medical treatment of hair loss.

Scientists in the U.S. and Britain may have come much closer to finding a cure for baldness.  For the first time they have generated new hair follicles that grow human hair.  The method involved harvesting cells from the base of a human hair follicle, or dermal papillae, and cloning them in the laboratory.  They then implanted these cloned cells into human skin grafted, or attached, to the back of a mouse. The dermal papillae cells were taken from seven different human donors.  Of the seven cases, five of the mice grew new hair on the grafted skin.

The same technique still needs to be translated into human trials, but there is hope for revolutionary treatment for hair loss in the not so distant future.  If this method works in human trials, there are many potential benefits, such as growing hair follicles for traditional transplantation, skin grafts for burn victims, and creating new hair follicles by direct injection of cells into the scalp.  This is especially beneficial for women, who historically have had a more difficult time responding to transplantation, and other medical treatments for balding.

Although researchers have not been able to reverse hair loss, or stop the physical process of balding, this breakthrough could mean a remedy for hair loss in the form of regenerative medicine, the body using its own cells to restore hair, at least. New research will also allow drug companies to test any number of compounds on growing hair follicles.  This advance could help in the discovery of new drug therapies to combat baldness.

Current clinically proven treatments include finasteride, (Proscar/Propecia) and Minoxidil (Rogaine).  Finasteride was first marketed as 5 mg pills to treat enlargement of the prostate under the brand name Proscar. In 1998, a 1 mg version with the brand name Propecia entered the market as the first pill approved by the FDA for men’s hair loss.  Similarly, Minoxidil which was first used in pill form as a medicine to treat high blood pressure, had the interesting side effect of excessive hair growth in those who took it.  Upon further research, a solution of minoxidil applied directly to the scalp was shown to also stimulate hair growth. We see this solution on shelves everywhere in the form of Rogaine.

If you are a man over 40 taking Propecia or finasteride to halt hair loss, contact your physician to talk about the effects it may have on your PSA blood test.  Due to the fact that finasteride has been shown to lower PSA levels, a good rule of thumb when getting your PSA blood test is to double the result.  The doubled number will be closer to your actual PSA level.

A version of this article appeared on

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David Samadi, MD - Medical Contributor

View posts by David Samadi, MD - Medical Contributor
Dr. Samadi is a board-certified urologic oncologist trained in open and traditional and laparoscopic surgery and is an expert in robotic prostate surgery. He is chairman of urology, chief of robotic surgery at Lenox Hill Hospital and professor of urology at Hofstra North Shore-LIJ School of Medicine. He is a medical correspondent for the Fox News Channel's Medical A-Team. Learn more at Visit Dr. Samadi's blog at Follow Dr. Samadi on Twitter, Instagram, Pinterest, and Facebook.
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